Each of the fields I have worked in – computer science, genetics, management consulting, biotechnology – has its own 2×2 matrices. Computer science and medicine have contingency tables (true positives, false positives, true negatives, false negatives), genetics has the Punnett square (Homozygous reference (AA), heterozygous (Aa) in the diagonals, and Homozygous alternate (aa)), and management consulting has the Eisenhower matrix (Urgent and important, urgent but not important, not urgent but important, not urgent and not important) and the BCG Growth-Share Matrix (High growth-high share, high growth-low share, low growth-high share, low growth-low share).
The attractiveness of 2×2 matrices comes from them being easy to grasp. It’s probably not a coincidence that I don’t remember ever having gotten anything but the most trivial insights out of a presentation featuring a 2×2 matrix.
Nehaveigur 