Information Content of the Genome

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On Asimov Press, Dynomight asks how information there is in DNA.

How should we define the “information content” of DNA? I propose a definition I call the “phenotypic Kolmogorov complexity”. Roughly speaking, this is how short you could make DNA and still get a “human” […] So what would this number be? My guess is that you could reduce the amount of DNA [in the human genome] by at least 75 percent, but not by more than 98 percent, meaning the information content is [60 MB to 750 MB].

I agree that this is a reasonable definition and estimate. The biggest unknown is what proportion of the human genome is junk DNA, even though Dynomight avoids using that term.

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